UPLC-ES/MS/MS Analysis of Amphetamine, Methamphetamine and Methylphenidate in Rat Serum using Supported Liquid Extraction

机译：使用负载液提取的大鼠血清中Amphetamine，甲基苯丙胺和甲基酚的UPLC-ES / MS / MS分析

获取原文

页面导航

摘要
著录项
相似文献
相关主题

摘要

A UPLC/ES-MS/MS method in conjunction with Supported Liquid Extraction was developed and validated for the quantification of amphetamine, methamphetamine, and methylphenidate using stable labeled internal standards. The data generated from this study will help correlate internal doses with physiological measurements in rats dosed with these compounds individually and provide further information about the potential neurotoxicity associated with these therapeutic drugs, which also have potential for abuse.

机译：开发并验证了使用稳定标记的内标的稳定标记的内标的稳定的液体萃取和验证了与负载液体萃取的UPLC / ES-MS / MS方法，并验证了稳定的标记的内标的甲基酚。本研究生成的数据将有助于与这些化合物单独给予的大鼠的物理测量相关的内部剂量，并提供有关与这些治疗药物相关的潜在神经毒性的进一步信息，这也具有滥用潜力。

著录项

来源
《American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics》|2011年||共1页
会议地点
作者
Nathan C. Twaddle; Michelle M. Vanlandingham; Mark Levi; John F. Bowyer; Lee D. Williams; Daniel R. Doerge;
展开▼
作者单位

展开▼
会议组织
原文格式 PDF
正文语种
中图分类 TB994.5-53;
关键词

相似文献

外文文献
中文文献
专利

1. Chromatographic separation of R-(-)/S-(+)-enantiomers of amphetamine and methamphetamine: differentiation between single methamphetamine consumption and co-consumption with amphetamine using enantioselective quantitative LC-MS/MS analysis [J] . Hess Cornelius, Losacker Moritz, Maas Alexandra International journal of legal medicine . 2019,第2期

机译：r - （ - ）/ s - （+） - 甲基苯丙胺的对映体的色谱分离：使用对映选择性定量LC-MS / MS分析的单一甲基苯丙胺消费和共消耗的分化
2. Simultaneous Quantification of Amphetamine and Methamphetamine in Meconium using ISOLUTE((R)) HM-N-Supported Liquid Extraction Columns and GC-MS. [J] . Gunn JA, Sweeney B, Dahn T, Journal of Analytical Toxicology . 2008,第7期

机译：使用HM-N支持的液相萃取柱和GC-MS同时定量检测胎粪中的苯丙胺和甲基苯丙胺。
3. Supported liquid extraction versus liquid-liquid extraction for sample preparation in LC-MS/MS-based bioanalysis [J] . Bioanalysis . 2013,第3期

机译：基于LC-MS / MS的生物分析中支持的液体萃取与液-液萃取进行样品制备
4. UPLC-ES/MS/MS Analysis of Amphetamine, Methamphetamine and Methylphenidate in Rat Serum using Supported Liquid Extraction [C] . Nathan C. Twaddle, Michelle M. Vanlandingham, Mark Levi, American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：使用负载液提取的大鼠血清中Amphetamine，甲基苯丙胺和甲基酚的UPLC-ES / MS / MS分析
5. Chiral Separation of the Enantiomers of Ephedrine, Amphetamine, Methamphetamine, MDA, MDMA, and Phentermine in Blood Using LC-MS/MS [D] . Vallier, Ashley Marie. 2018

机译：使用LC-MS / MS在血液中的偏黄素，amphetamine，甲基苯丙胺，MDA，MDMA和芬特勒的对映异构体的手性分离
6. Analysis of amphetamine and methamphetamine contents in seized tablets from Jazan Saudi Arabia by liquid chromatography-mass spectroscopy (LC-MS/MS) and chemometric techniques [O] . Hassan A. Alhazmi, Waquar Ahsan, Mohammed Al Bratty, 2020

机译：液相色谱-质谱（LC-MS / MS）和化学计量技术分析沙特阿拉伯Jazan缉获的片剂中苯丙胺和甲基苯丙胺的含量
7. Simple and Rapid Method for Determination of Abemaciclib in Human Serum using Supported Liquid Extraction Pretreatment and LC-MS/MS Analysis [O] . Naoto Sekizaki, Hideaki Yashima, Takuya Araki, 2021

机译：使用负载液提取预处理和LC-MS / MS分析测定人血清中ABEMACIB的简单且快速的方法
8. GC/MS (Gas Chromatography-Mass Spectrometry) Analysis of Organics in Drinking Water Concentrates and Advanced Waste Treatment Concentrates. Volume 3. Batch Liquid-Liquid Extraction and Analysis of 10-Liter Sample and Analysis of Concentrates from Small Volumes (10 to 50 Liters) of Drinking Water [R] . Lucas, S. V. 1984

机译：GC / ms（气相色谱 - 质谱）分析饮用水浓缩物和先进废物处理浓缩物中的有机物。第3卷。批量液 - 液萃取和分析10升样品并分析小体积（10至50升）饮用水中的浓缩物

UPLC-ES/MS/MS Analysis of Amphetamine, Methamphetamine and Methylphenidate in Rat Serum using Supported Liquid Extraction

摘要

著录项

相似文献

相关主题

期刊订阅