Automated Quantitative Analysis of LC-MS/MS Data with Isobaric Tags or Stable Isotope Labeling in MassMatrix Database Search Engine

摘要

We have demonstrated that reliable LC-MS/MS based quantitative proteomic analysis using TMT and SILAC labeling can be achieved in MassMatrix database search engine for a large mixture of proteins with small to large fold changes and a large dynamic range of protein concentrations.