Oxythiaminespecifically inhibits heat shock protein 27 (Hsp27) phosphorylationand cell proliferation in MIA pancreatic cancer cells

摘要

Oxythiamine (OT), an inhibitor of transketolase enzyme, is known to inhibit pancreatic cancer cell proliferation. In this study, we investigated the molecular mechanisms of the anti-proliferative action of OT at both translational and post-translational levels in MIA PaCa cancer cells using proteomic techniques. We hypothesized that OT interferes with cell cycle activity through changes in phosphorylation of cellular proteins.