Leptin Fragment Increase Hematopoietic Stem Cell Population and Improve its Engraftment Ability

摘要

Several studies have shown the important actions of cytokine leptin that regulates food intake and energy expenditure. Additionally, the ability to modulate hematopoiesis has also been demonstrated increasing hematopoietic progenitors. Previous reports of our group have shown that some synthetic sequences of leptin molecules can activate leptin receptor [1-3]. Herein, decapeptides encompassing amino acids from positions 98 to 122 of the leptin molecule were constructed to evaluate their effects on hematopoiesis [4].