SOLID-PHASE PEPTIDE SYNTHESIS USINGNANOPARTICULATE AMINO ACIDS IN WATER

摘要

Solid-phase synthesis has been developed and automated in the field of peptide synthesis, and is currently being applied to general organic synthesis along with the spread of combinatorial chemistry. However this procedure requires a large amount of organic solvents. Because the safe organic solvent waste disposal is an important environmental issure, a method for peptide synthesis in water using low toxic reagents would be desirable. We developed solid phase peptide synthesis in water using water-soluble protected amino acids. Here we develop a new technology for solid phase peptide synthesis using nanoparticulate amino acids in water.