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EFFECT OF NEAR-UV IRRADIATION ON A SINGLE CHAIN VARIABLE FRAGMENT OF THE MONOCLONAL ANTIBODY 82D6A3 AND ITS MUTANTS

机译：接近UV辐射对单克隆抗体82d6a3的单链可变片段及其突变体的影响

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Proteins are targets for photo-destruction due to absorption of incident light by endogenous chromophores. The near-UV light can induce changes in the protein structure due to the disruption of disulfide bonds upon excitation of a nearby Trp-residue. Mass spectroscopic data presented evidence that structural modification observed upon irradiation of goat alpha-lactalbumin at 290 nm results from tryptophan (Trp) mediated cleavage of disulfide bonds.

机译：由于内源发色团吸收入射光，蛋白质是光损伤的靶标。近紫外光可以引起蛋白质结构的变化，因为在附近的TRP残基激发时染发剂粘连。质谱数据呈现证据，即在290nm介导的色氨酸（TRP）介导的二硫键切割的结果上观察到在山羊α-乳白蛋白的结构改性。

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《the European Peptide Symposium 》|2007年||共2页
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Eszter Illyes; Stephanie Staelens; Ann Vanhooren;
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6. EFFECT OF NEAR-UV IRRADIATION ON A SINGLE CHAIN VARIABLE FRAGMENT OF THE MONOCLONAL ANTIBODY 82D6A3 AND ITS MUTANTS [C] . Eszter Illyes, Stephanie Staelens, Ann Vanhooren the European Peptide Symposium . 2007

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EFFECT OF NEAR-UV IRRADIATION ON A SINGLE CHAIN VARIABLE FRAGMENT OF THE MONOCLONAL ANTIBODY 82D6A3 AND ITS MUTANTS

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