PROFILING OF MEMBRANE LIPIDS RELEVANT TO ALZHEIMER'S DISEASE PATHOGENESIS

摘要

Alzheimer's disease (AD) is the most common cause of dementia (60-80% of cases) in elderly population worldwide [1]. The current body of research supports the concept that protein aggregation initiates the onset of AD [2]. However, in spite of the large number of studies, a mechanism of pathogenesis and potential treatment for AD remains elusive. We explored the distribution of membrane lipids (gangliosides) as they supposedly trigger protein aggregation [3].