首页> 外国专利> compound, process for preparing a compound, pharmaceutical formulation, use of a compound, methods of treating and / or preventing lipid disorders (dyslipidemia) associated or not with insulin resistance, and atherosclerosis, methods of treatment and / or prophylaxis of cardiovascular disease, hypercholesterolemia, conditions associated with the need to improve reverse cholesterol transport, and to decrease cholesterol absorption in the intestine, to increase HDL cholesterol levels, to lower cholesterol levels. ldl, inflammatory conditions, alzheimer's disease, type 2 diabetes arteriosclerosis, conditions associated with the need to improve hdl function, and pharmaceutical composition

compound, process for preparing a compound, pharmaceutical formulation, use of a compound, methods of treating and / or preventing lipid disorders (dyslipidemia) associated or not with insulin resistance, and atherosclerosis, methods of treatment and / or prophylaxis of cardiovascular disease, hypercholesterolemia, conditions associated with the need to improve reverse cholesterol transport, and to decrease cholesterol absorption in the intestine, to increase HDL cholesterol levels, to lower cholesterol levels. ldl, inflammatory conditions, alzheimer's disease, type 2 diabetes arteriosclerosis, conditions associated with the need to improve hdl function, and pharmaceutical composition

机译:化合物,化合物的制备方法,药物制剂,化合物的用途,治疗和/或预防与胰岛素抵抗相关或不相关的脂质疾病(血脂异常)和动脉粥样硬化的方法,心血管疾病,高胆固醇血症的治疗和/或预防方法与需要改善胆固醇逆向转运,减少肠内胆固醇吸收,增加HDL胆固醇水平,降低胆固醇水平相关的疾病。 ldl,炎性疾病,阿尔茨海默氏病,2型糖尿病动脉硬化,与需要改善hdl功能相关的疾病以及药物成分

摘要

"COMPOUND, PROCESS FOR THE PREPARATION OF A COMPOUND, PHARMACEUTICAL FORMULATION, USE OF A COMPOUND, METHODS OF TREATMENT AND / OR PREVENTION OF LIPID DISORDERS (DISLIPIDEMIA) ASSOCIATED OR NOT WITH INSULTATION AND INSULTATION RESISTANCE, OR PROFILAXY OF CARDIOVASCULAR DISEASE, HYPERCOLESTEROLEMIA, CONDITIONS ASSOCIATED WITH THE NEED TO IMPROVE REVERSE CHOLESTEROL TRANSPORT, AND TO DIMINATE COLESTEROL ABSORPTION IN THE INTESTINE OF NIN-SIMULAR DIMENSIONS LDL CHOLESTEROL OF INFLAMMATORY CONDITIONS, MAL ALZHEIMER, ARTERIOSCLEROSIS, TYPE 2 DIABETES, CONDITIONS ASSOCIATED WITH THE NEED TO IMPROVE HDL FUNCTION AND PHARMACEUTICAL COMPOSITION ". The invention relates to certain novel compounds of Formula (I): to processes for preparing them, to their utility in modulating Nuclear Receptor-Liver (LXR) 244 (NR1H3) and / or 225) hormone receptors (NR1H2) and in the treatment and / or prevention of clinical conditions including cardiovascular diseases such as atherosclerosis; inflammatory diseases, Alzheimer's disease, lipid disorders (dyslipidemias) associated or not with insulin resistance, type 2 diabetes and other manifestations of the metabolic syndrome, methods for their therapeutic use and pharmaceutical compositions containing them.
机译:“化合物,制备过程,药物配方,化合物的使用,治疗和/或预防脂病(脂溢性)的方法,与或未与绝缘和感染抵抗有关,或与结肠癌,结肠癌相似,伴随着需要改善逆向胆固醇转运,并消除肠道内的LN胆固醇,如炎症状况,恶性疟疾,动脉硬化,2型糖尿病(视病情而定),其胆固醇水平很低。 ”。本发明涉及某些式(I)的新化合物:制备它们的方法,其在调节核受体-肝(LXR)<244>(NR1H3)和/或<225)激素受体>(NR1H2)中的用途和治疗和/或预防包括心血管疾病(如动脉粥样硬化)在内的临床疾病;炎性疾病,阿尔茨海默氏病,与胰岛素抵抗相关或不相关的脂质疾病(血脂异常),2型糖尿病和代谢综合征的其他表现,其治疗用途和含有它们的药物组合物。

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