SWEET HRMS WORKFLOW STRATEGY FOR SCREENING UNHEALTHY SUBSTANCES IN FOOD

摘要

As more and more new food compounds are being developed and deployed around the world, contaminants not in target lists can appear in products through environmental or manufacturing contamination or misuse. This makes it essential that food safety laboratories stay vigilant for an everincreasing number of analytes to screen for, and for new, unexpected and unwanted compounds[1] [2]. At the moment, the LC triple quad MS and GC triple quad MS systems are the workhorses of the pesticide laboratory. Most labs in Europe still use these technologies more than any other. But there's a trend toward implementing high-resolution accurate mass (HRAM) technology, because analysts are no longer satisfied with just finding the expected compounds in the samples; now, the aim is to identify everything (or at least as much as possible). In other words, there is a steady move away from targeted analysis. Screening allows us to discover what is in the samples with less bias - at odds with simply looking for what we already suspect is present. This poster will show an efficient workflow fora non-targeted acquisition MS-mode for different compound groups and demonstrate a next-generation workflow for more efficient control of unexpected and unwanted compounds in food. The Swedish Ethyl acetate multiresidue method (SweEt), coupled with a high-resolution mass spectrometer offers: 1. The ability to screen for several compound groups at the same time, in the same sample; 2. Advanced software tools for screening evaluation and identification; 3. A validated and accredited method to screen for around 500 pesticides in fruits and vegetables.