1,1,1,3,3,3-Hexafluoroisopropanol as a Media of Choice for Electrophilic Alkylation of π-donors in the Absence of Lewis Acids(Abstracts)

摘要

Owing to the unique properties (high ionizing power and low nucleophilicity) 1,1,1,3,3,3-hexafluoroisopropanol (HFIP) was shown to he an almost ideal solvent for performing a number of transformations such as selective oxidation, oxirane ring opening and aza-Diels-Alder reactions . Here we wish to present the data attesting to the usefulness of HFIP as a specific media securing an opportunity to carry out the electrophilic alkylations of various π-donors under remarkably mild conditions in the absence of any Lewis acids.