Analysis of Monoclonal Immunoglobulins and Multiple Myeloma Model by Use of 21 Tesla FT-ICR MS

摘要

Monoclonal immunoglobulin intact light chain isotopically baseline-resolved with 0.2 ppm rms error on a chromatographic time-scale 82% sequence coverage achieved from combined ETD and CID for adalimumab Method developed for monoclonal immunoglobulin detection, identification, quantitation, and light chain isotyping in multiple myeloma model Method to be used to define the mutational status of malignant plasma cells by monitoring the monoclonal immunoglobulins secreted by those cells.