Role of Protein Oxidation in Amyloid Fibril Formation Assemblies

摘要

Protein oxidation has been implicated with a wide range of disease and aging [1]. Reactive oxygen species (ROS) contribute to processes that induce irreversible structural damage and alter protein activity. Oxygen containing radicals and in particular the hydroxyl radical react with proteins through hydrogen abstraction, addition and elimination reactions at both the amino acid residue side chains and backbone amide bonds to produce oxidized, degraded, and cross-linked proteins [1-4]. We are investigating the role of amino acid side chain oxidation in amyloid assemblies by comparing the fibril formation kinetics of native and oxidized proteins [5].