Cross beta structure comprising amyloid binding proteins and methods for detection of the cross beta structure, for modulating cross beta structures fibril formation and for modulating cross beta structure-mediated toxicity

摘要

The present invention relates to modulating extracellular protein degradation and/or protein clearance by modulating the cross-beta structure formation or tissue plasminogen activator-like activity, treatment of amyloidosis-type diseases by modulating the cross-beta structure, and diagnosis of amyloidosis-type diseases by visualising cross-beta structure.