Long term recreational physical exercise decreases angina susceptibility and reduces myocardial infarct size

摘要

Introduction: Physical inactivity, i.e. sedentary life style increases cardiovascular disease risk. Carbon monoxide and nitric oxide produced by the heme oxygenase (HO) and by the constitutive nitric oxide synthase (cNOS) protect circulation. We examined the effects of recreational physical exercise on the expression of these enzyme systems in conjunction with cardiovascular protection.Design: Male Wistar rats were placed into cages installed with running wheels allowing them voluntary physical exercise over 6 weeks. We studied 1. the activity and expression of HO and NOS in the aorta and left ventricle (LV); 2. the angina susceptibility of the heart (assessed by lead II. surface ECG following adrenaline plus phentolamine challenge); 3. the infarct size was measured in isolated hearts from both groups (control and trained) and subjected to 30 min coronary occlusion followed by 120 min reperfusion