Enhanced dissolution of CRS 74 microcrystals prepared by antisolvent crystallization process using hydrophilic additives.

摘要

This study concerns a new compound, (2S, 3S, 5S)-2, -5 bis-[N-[N-[[N-methyl-N-[(2-isopropyl-4-tiazolyl) methyl] amino] carbonyl] vanilyl] amino-1,6-diphenyl-3-hydroxyhexane, named CRS 74. This molecule has activity for inhibiting HIV protease, an essential enzyme involved in HIV replication process. Consequently, this new compound can be used for the treatment of HIV infections, itself or in combination with other anti-HIV medicines. Its chemical formula is C_(46)H_(66)N_8O_5S_2.