New advances in polarized light microscopy have been employed to image Congo red (CR) stained amyloid plaques in sharp relief. The roiating polarizer method has been used to produce separate false color maps of the transmission, linear birefringence (LB), orientation of the slow vibration direction, linear dichroism (LD), and orientation of the electric dipole transition moment. The consequences of these effects are typically convolved in an ordinary polarized light microscope. In this way, we show that the Alzheimer's plaques have disordered cores and radial distributions of CR.
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