INVESTIGATION OF CALCIUM PECTINATE GEL BEADS AS AN INTRAGASTRIC FLOATING DRUG DELIVERY SYSTEM: USING CARBONATES AS A GAS-FORMING AGENT

摘要

A new intragastric floating drug delivery system using calcium pectinate gel beads was designed. The effect of some formulation variables (e.g. carbonate salts, acidity of medium, pectin type, etc.) on buoyancy and morphology of the beads was studied. The beads floated in gastric conditions due to their porous structure.