Conformational analysis of peptides derived from feline immunodeficiency virus TM-glycoprotein

摘要

Feline immunodeficiency virus (FIV) is a pathogen that causes an AIDS-like syndrome in domestic cats and is extensively used as a model system by which criteria for antilentiviral vaccines and drugs development ca be tested (1).Initiation of cell infection by lentiviruses is a complex process involving multiple interactions between the glycoproteins (gp) of the viral envelope (Env) and molecules of the cell surface,with the transmembrane (TM) gp mediating the final event of membrane fusion and virus entry.