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The synthesis of aminomethyl substituted azaphenylalanine derivatives as thrombin inhibitors

机译：氨基甲基取代的亚本子甘氨酸衍生物作为凝血酶抑制剂的合成

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The serine protease thrombin is a key enzyme in the control of blood coagulation and displays numerous other effects in the orgaism.Thus a potent and selective thrombin inhibitor could be beneficially used in the treatment of several cardiovascular disorders.

机译：丝氨酸蛋白酶凝血酶是控制血液凝固中的关键酶，并且在操作系统中显示许多其他效果。效力和选择性凝血酶抑制剂可以有利地用于治疗几种心血管障碍。

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《European Peptide Symposium》|2002年||共2页
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Ales Obreza; Uros Urleb;
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中图分类氨基酸、肽、蛋白质;
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专利

1. Novel non-covalent azaphenylalanine thrombin inhibitors with an aminomethyl or amino group at the P1 position. [J] . Obreza A, Stegnar M, Urleb U Die Pharmazie . 2004,第9期

机译：新型的非共价氮杂苯丙氨酸凝血酶抑制剂，在P1位具有氨基甲基或氨基。
2. Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives [J] . Guillon Jean, Cohen Anita, Boudot Clotilde, Trends in Ecology & Evolution . 2020,第1期

机译：新的2,4-BIS [（取代 - 氨基甲基）苯基]喹啉，1,3-双[（取代 - 氨基甲基）苯基]异喹啉和2,4-双（取代 - 氨基甲基）的喹啉苯基]喹唑啉衍生物
3. Design, synthesis, and antiprotozoal evaluation of new 2,4-bis[(substituted-aminomethyl)phenyl]quinoline, 1,3-bis[(substituted-aminomethyl)phenyl]isoquinoline and 2,4-bis[(substituted-aminomethyl)phenyl]quinazoline derivatives [J] . Jean Guillon, Anita Cohen, Clotilde Boudot, Journal of enzyme inhibition and medicinal chemistry. . 2020,第1期

机译：新的2,4-双[（取代氨基甲基）苯基]喹啉，1,3-双[（取代 - 氨基甲基）苯基]异喹啉和2,4-双（取代 - 氨基甲基）的设计，合成和抗丙二醇评价苯基]喹唑啉衍生物
4. The synthesis of aminomethyl substituted azaphenylalanine derivatives as thrombin inhibitors [C] . Ales Obreza, Uros Urleb European Peptide Symposium . 2002

机译：氨基甲基取代的亚本子甘氨酸衍生物作为凝血酶抑制剂的合成
5. Spectroscopic studies on carborane derivatives: Synthesis and characterization of partial cage degradation reactions of 1,2-(hydroxymethyl radical)-closo-carborane with 2-(aminomethyl)-pyridine. [D] . Gilbes, Blanca Janet. 2006

机译：碳硼烷衍生物的光谱研究：1,2-（羟甲基自由基）-氯甲烷与2-（氨基甲基）-吡啶的部分笼降解反应的合成和表征。
6. Design synthesis and antiprotozoal evaluation of new24-bis(substituted-aminomethyl)phenylquinoline13-bis(substituted-aminomethyl)phenylisoquinoline and24-bis(substituted-aminomethyl)phenylquinazoline derivatives [O] . Jean Guillon, Anita Cohen, Clotilde Boudot, 2020

机译：新产品的设计合成和抗原生动物评估24-双（取代的氨基甲基）苯基喹啉13-双（取代的氨基甲基）苯基异喹啉和24-双（取代-氨基甲基）苯基喹唑啉衍生物
7. Synthesis of 2-(Substituted-phenyl)-5-(aminomethyl)- and (thiomethyl)-1,3,4-oxadiazoles: Oxidation of Thiomethyloxadiazole Derivatives by Dimethyldioxirane [O] . Kiss-Szikszai, Attila, Patonay, Tamás, Jekő, József 2017

机译：2-（取代基 - 苯基）-5-（氨基甲基） - 和（硫代甲基）-1,3,4-恶二唑的合成：二甲基二环氧乙烷氧化硫代甲基恶二唑衍生物

The synthesis of aminomethyl substituted azaphenylalanine derivatives as thrombin inhibitors

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