Promotion of growth of colonic cancer cells by N-carboxymethyl gastrin through a non-CCK2 receptor

摘要

N-carboxymethyl gastrin (G17-Gly) is the major gastrin gene product in colonic cancers [1] and has been shown to stimulate the growth of both DLD-1 and HT-29 human colon cancer cell lines.Using saturation binding studies,Stepan and associates identified a high affinity binding site for G17-GLy on HT-29 cells [1].