Novel synthetic approaches to potent HIV-1 protease inhibitors and prodrugs

摘要

Introduction of HIV-protease inhibitors (PIs) as a part of the Highly Active Antiretroviral Therapy (HAART),resulted in a dramatic decrease of mortality from AIDS in the developed world.However high pill burden of PIs,caused in part by their limited solubility,can result in an inadquenate patient compliance,and a subsequent rebound of HIV.