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Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants

机译：新型HIV-1蛋白酶抑制剂（PI）（GRL-001-15和GRL-003-15）的卤素键相互作用与蛋白酶的襟翼对其具有野生型HIV-1和多功能抗性的有效活性至关重要变体

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Shin-ichiro Hattori; Hironori Hayashi; Haydar Bulut; Kalapala Venkateswara Rao; Prasanth R. Nyalapatla; Kazuya Hasegawa; Manabu Aoki; Arun K. Ghosh; Hiroaki Mitsuya;
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1. Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants [J] . Hattori Shin-ichiro, Hayashi Hironori, Bulut Haydar, Antimicrobial agents and chemotherapy. . 2019,第6期

机译：新型HIV-1蛋白酶抑制剂（PI）（GRL-001-15和GRL-003-15）的卤素键相互作用与蛋白酶的翼片至关重要对野生型HIV-1和多功能抗性的有效活性至关重要变体
2. GRL-0519, a novel oxatricyclic ligand-containing nonpeptidic HIV-1 protease inhibitor (PI), potently suppresses replication of a wide spectrum of multi-PI-resistant HIV-1 Variants in Vitro [J] . AmanoM., TojoY., Salcedo-GómezP.M., Antimicrobial agents and chemotherapy. . 2013,第5期

机译：GRL-0519是一种新型的含三环配体的非肽类HIV-1蛋白酶抑制剂（PI），可有效抑制多种耐多PI的HIV-1变体的体外复制
3. Novel HIV-1 protease inhibitors (PIs) containing a bicyclic P2 functional moiety, tetrahydropyrano-tetrahydrofuran, that are potent against multi-PI-resistant HIV-1 variants. [J] . Ide K, Aoki M, Amano M, Antimicrobial agents and chemotherapy. . 2011,第4期

机译：新型的HIV-1蛋白酶抑制剂（PIs）包含双环P2功能部分，四氢吡喃基-四氢呋喃，对多种抗PI的HIV-1变体有效。
4. Novel synthetic approaches to potent HIV-1 protease inhibitors and prodrugs [C] . Wieslaw Kazmierski, Eric Furfine, Andrew Spaltenstein, European Peptide Symposium . 2002

机译：具有强效HIV-1蛋白酶抑制剂和前药的新型合成方法
5. Structure based design of potent inhibitors against multidrug-resistant HIV-1 protease variants. [D] . Yedidi, Ravikiran S. 2009

机译：基于结构的抗多药HIV-1蛋白酶变体有效抑制剂的设计。
6. Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants [O] . Shin-ichiro Hattori, Hironori Hayashi, Haydar Bulut, 2019

机译：新型的HIV-1蛋白酶抑制剂（PI）（GRL-001-15和GRL-003-15）与蛋白酶瓣的卤素键相互作用对于其对野生型HIV-1和多抗PI的有效活性至关重要变体
7. GRL-0519, a Novel Oxatricyclic Ligand-Containing Nonpeptidic HIV-1 Protease Inhibitor (PI), Potently Suppresses Replication of a Wide Spectrum of Multi-PI-Resistant HIV-1 Variants In Vitro [O] . Masayuki Amano, Yasushi Tojo, Pedro Miguel Salcedo-Gómez, 2013

机译：GRL-0519，一种新的含氧酸碱配体的非肽肽HIV-1蛋白酶抑制剂（PI），有效地抑制了体外宽谱的复制的多型多功率HIV-1变体

Halogen Bond Interactions of Novel HIV-1 Protease Inhibitors (PI) (GRL-001-15 and GRL-003-15) with the Flap of Protease Are Critical for Their Potent Activity against Wild-Type HIV-1 and Multi-PI-Resistant Variants

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