Chiral high-performance liquid chromatographic enantioseparation of alpha-substituted proline analogues

摘要

In the past decade,great efforts have been made to obtain receptor-selective ligands with conformationally constrained structures.The alpha-and beta-substituted amino acids are important structural features of highly constrained peptide systems.The synthsis of these unnatural amino acids either leads to a reacemate,which is usually the fastest process or the asymmetric synthesis may afford a product whose enantiomeric purity often does not attain 100%.