Development of peptidomimetic substrates and inhibitors that bind to the peptide binding pocket of the catalytic site of p60~(C-src) protein tyrosine kinase

摘要

Src family protein tyrosine kinases (PTKs) are excellent targets for anti-cancer drug discovery due to their association with cell transformation and carcinogenesis.In the past few years,we have developed a pseudosubstrate-base inhibitor strategy to target the active site of p60~(C-src). PTK.