TAXI, A NEW CLASS OF ENZYME INHIBITORS

摘要

Wheat arabinoxylans consist of a linear backbone of 1,4-linked beta-D-xylopyranose units. L-Arabinofuranosyl residues are attached to the main chain by 1,3- and/or 1,2-alpha-glycosidic linkages. Phenolic acids, such as ferulic acid and p-coumaric acid, can be ester-linked to 0-5 of the arabinofuranose units. Arabinoxylan can be degraded by several enzymes. The 1,4-beta-D-xylanhydrolases (EC 3.2.1.8), further referred to as endoxylanases, generate unsubstituted and substituted xylo-oligosaccharides. These oligomers are further degraded by beta-D-xylosidases (EC 3.2.1.37), releasing bet-D-xylose from the non-reducing end. The alpha-L-arabinose substituents from the main chain are liberated by alpha-L-arabinofuranosidases (EC 3.2.1.55). Finally, esterases (EC 3.1.1.6) release ferulic and p-coumaric acids esterified to O-5 of arabinofuranosyl residues.