Microscopic acid dissociation and complex formationof polyacryloyllysine

摘要

In general, aminocids exists in protonated and deprotonated forms in acidic and basic regions, respectively. While there is coexistence of zwitterionic and neutral forms in neutral pH-region. Such a behavior that distribution of microscopic forms depends on pH values is one of the characteristics of amphoteric compounds. Microscopic acid dissociation of the amphoteric polymer having both amino and carboxyl groups is of interest in connection of bioactive polymers. There is no report on microscopic acid dissociation of synthetic polymers in spite of many works on macroscopic acid dissociation of polyelectrolytes. In addition, Polyamino acids are expected to have excellent complexing ability because of a synergistic effect of amino and carboxyl groups. This paper deals with microscopic acid dissociation and complexation of polyacryloyllysine (PAK) and isobutyryllysine (IBK) that is a model compound of PAK.