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Advancement of dna vaccines to human clinical trials

机译：DNA疫苗对人体临床试验的推进

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DNA or genetic vaccines are currently being evaluated for safety and efficacy in human clinical trials in the areas of infectious disease and cancer. Since DNA vaccines induce antibodies and cytotoxic T lymphocytes (CTL's), they are currently being evaluated for both prevention and therapy.

机译：目前正在评估DNA或遗传疫苗，用于传染病和癌症领域的人类临床试验中的安全性和疗效。由于DNA疫苗诱导抗体和细胞毒性T淋巴细胞（CTL），目前正在评估预防和治疗。

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《International symposium on controlled release of bioactive materials 》|1998年||共2页
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Richard B. Ciccarelli;
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中图分类生物材料学 ;
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1. Clinical trial in healthy malaria-na?ve adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA [J] . RichieT.L., CharoenvitY., WangR., Human vaccines & immunotherapeutics. . 2012 ,第11期

机译：在未患疟疾的健康成年人中进行临床试验，以评估MuStDO5的安全性，耐受性，免疫原性和功效，MuStDO5是一种五基因子孢子/肝阶段恶性疟原虫DNA疫苗，并逐步增加剂量的人GM-CSF DNA
2. Clinical trial in healthy malaria-naive adults to evaluate the safety, tolerability, immunogenicity and efficacy of MuStDO5, a five-gene, sporozoite/hepatic stage Plasmodium falciparum DNA vaccine combined with escalating dose human GM-CSF DNA [J] . Thomas L. Richie, Yupin Charoenvit, Ruobing Wang, Human vaccines . 2012 ,第11期

机译：一项针对未患疟疾的健康成年人的临床试验，以评估MuStDO5的安全性，耐受性，免疫原性和功效，MuStDO5是一种五基因子孢子/肝阶段恶性疟原虫DNA疫苗，并逐步增加剂量的人GM-CSF DNA
3. Characterization and preclinical evaluation of the cGMP grade DNA based vaccine, AV-1959D to enter the first-in-human clinical trials [J] . Neurobiology of disease . 2020 ,第期

机译：CGMP级DNA疫苗的表征与临床前评价，AV-1959D进入一生临床试验
4. Advancement of dna vaccines to human clinical trials [C] . Richard B. Ciccarelli, Ph.D International symposium on controlled release of bioactive materials;Consumer and diversified products conference . 1998

机译：脱氧核糖核酸疫苗在人类临床试验中的进展
5. Clinical predictive value of pre-clinical cancer models: A study of the predictive value of the in vitro cell line, human xenograft and murine allograft pre-clinical cancer models for phase II clinical trials of cytotoxic cancer drugs [D] . Voskoglou-Nomikos, Theodora 2001

机译：临床前癌症模型的临床预测价值：体外细胞系，人异种移植和小鼠同种异体移植临床前癌症模型对细胞毒性癌症药物II期临床试验的预测价值研究
6. Safety and tolerability of HIV-1 multiantigen pDNA vaccine given with IL-12 plasmid DNA via electroporation, boosted with a recombinant vesicular stomatitis virus HIV Gag vaccine in healthy volunteers in a randomized, controlled clinical trial [O] . Marnie L. Elizaga, Shuying S. Li, Nidhi K. Kochar, 2012

机译：在随机，对照临床试验中，通过健康穿孔机注射重组水泡性口炎病毒HIV Gag疫苗增强IL-12质粒DNA的电穿孔和IL-12质粒DNA的HIV-1多抗原pDNA疫苗的安全性和耐受性
7. A human immunodeficiency virus 1 (HIV-1) clade A vaccine in clinical trials: stimulation of HIV-specific T-cell responses by DNA and recombinant modified vaccinia virus Ankara (MVA) vaccines in humans. [O] . Mwau, M, Cebere, I, Sutton, J, 2004

机译：人类免疫缺陷病毒1（HIV-1）进化枝A疫苗正在临床试验中：通过DNA和重组修饰的痘苗病毒安卡拉（MVA）疫苗刺激人的HIV特异性T细胞反应。
8. Gene Gun-Delivered DNA Vaccines for Hemorrhagic Fever With Renal Syndrome: Advancement to Clinical Trials [R] . Hooper, J. W., Badger, C. V., Brown, J. E., 2008

机译：Gene Gun-Derivered DNa疫苗用于治疗肾综合征出血热：临床试验进展

Advancement of dna vaccines to human clinical trials

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