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METHOD FOR MIMICKING HUMAN CLINICAL TRIAL BY USING NON-HUMAN ANIMALS
METHOD FOR MIMICKING HUMAN CLINICAL TRIAL BY USING NON-HUMAN ANIMALS
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机译:使用非人类动物模仿人类临床试验的方法
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摘要
The present invention provides a method for using non-human animals to mimick human clinical trial comprising: (a) obtaining cells or tissues from n human subjects suffered from a disease, wherein n1; (b) establishing a control group and a treatment group, wherein i) the control group comprises i control non-human animals, wherein i≧n, wherein cells or tissue from each human subject are grafted to at least one control non-human animal; ii) the treatment group comprises j treatment non-human animals, wherein j≧n, wherein cells or tissue from each human subject are grafted to at least one treatment non-human animal; and iii) each control non-human animal or treatment non-human animal is grafted with cells or tissues from one human subject; (c) administering a first agent to the control group and administering a second agent to the treatment group, wherein the first agent is different from the second agent; (d) obtaining the end point of the control group and the treatment group; and (e) comparing the end point of the control group to the end point of the treatment group.
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