Radiation Pneumonitis and Low Dose Radiation Hypersensitivity

摘要

Analysis of a University of Michigan (UMich) clinical trial dose-volume histogram (DVH) dataset is summarized, the goal of which was to improve radiation pneumonitis (RP) prediction. A family of dose-damage profiles featuring low-dose radiation hypersensitivity (RHS) achieved higher predictive accuracy than mean lung dose (MLD), motivating a novel RHS normal tissue complication probability (NTCP) model. Results of this model are summarized. If one makes reasonable assumptions regarding the institution-specific DVH mix, the model can reproduce published MLD-RP risk curves obtained in clinical trials at Duke University, Netherlands Cancer Institute (NKI), Washington University (WU) and the University of Milan (UMilan).