There has recently been a dramatic proliferation of research related to electronically generated metallic bactericidal ions. Unfortunately, there have been no literature reviews or discussions concerning metallic-nanoparticle suspension as a drug reservoir for iontophoretic application. Heavy metals, especially silver, are frequently used to treat infection before the development of systemic antimicrobial agents. For medical applications, conversion of colloidal silver into its ionic form is required, but not by direct use of silver salts to provide silver ions, as the counter-ions of silver salt may cause severe problems for the human body as the silver ion is consumed. The primary goal of this research is to develop an electronically driven system (EDS), which can provide a relatively safe bactericidal ion solution with a controllable electronic field. In this study, the UV-visible spectroscopy and ionic selective electrodes (ISE) are used to identify and observe activity details of the system throughout the course of the experiment. Both qualitative and quantitative data analyses are performed.
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