Automatic control of drug dosage for continuous infusion in anaesthesia using state space methods

摘要

This paper presents a dynamic pole placement procedure, based on a static state feedback to improve the performance of target control infusion (TCI) in the control of the neuromuscular blockade (NMB) level by administration of the muscular relaxant rocuronium. To apply this procedure, a novel identification method, based on the model structure, for the patient model parameters is proposed. The resulting individualized control method of drug dosage for continuous infusion was validated by simulations based on real data collected during surgeries.