Micronized Amnion/Chorion Delivery Promotes Mesenchymal Stem Cell Recruitment to the Supraspinatus Muscle After Rotator Cuff Injury

摘要

This study indicates that udHACM is able to recruit inflammatory and pro-healing cells to the supraspinatus muscle after severe rotator cuff injury. While there was recruitment of both Ml and M2-like macrophages by udHACM, these results are not significantly different from the number of these cells that were recruited due to injury only, which suggests that the material does not elicit an extreme pro-inflammatory response. Overall, the ability of udHACM to recruit MSCs to the muscle indicates that implantation of this material may be a promising method to promote muscle regeneration following rotator cuff injury, which is the subject of ongoing studies.