Numerical Modeling of Behavior of Cancer Cells after Electroporation

摘要

One of the approaches that could be used for cancer treatment is electroporation. This is a relatively new technique and thus its effect on various cancer cell types should be analyzed in detail. In this paper numerical simulations are used, in order to model the behavior of cells after electroporation. Fitting procedure was used for estimation of the parameters of the computer model. This model enables continuous tracking of changes in cell viability and provides some quantitative information about the effect of electric field (change in proliferation and death rate, oxygen consumption etc.). The accuracy of the model is validated using experimental data.