PLGA Docetaxel Nanoparticles: Preparation and In Vitro Evaluation

摘要

In this study PLGA nanoparticles containing docetaxel have been developed. The effect of different formulation parameters such as drug/polymer ratios, oil phase combination, volume and surfactant amount were evaluated. The size and size distribution and surface morphology of the nanoparticles were then investigated by laser light scattering and scanning electron microscopy. The drug encapsulation efficiency and in vitro release profiles were measured by HPLC. It was shown that the polymeric nanoparticles could provide a suitable release profile and exerts an adequate control on the drag diffusion rate.