Synthesis, characterization and antitumor activity of new transition metal and uranyl complexes

摘要

In this research, some of the inorganic complexes of uranyl with N- donor ligands were synthesized. Complexes were characterized by FT-IR and UV, "HNMR, ~(13)CNMR spectra, TG/DTG measurements and some physical properties. The results of simultaneous TG-DTG-DTA analyses of the complexes show the final degradation product for these complexes are UO_3. The antitumor activity of used ligands and their complexes against a panel of human tumor cell lines (HT29: Haman colon adenocarcinoma cell line T47D: human breast adenocarcinoma cell line) were studied and determined by MTT (3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide) assay. These data suggest that some of these compounds provide good models for the further design of potent antitumor materials. Also the results show chelation causes drastic change in the biological properties of the ligands and also the metal moiety. So the toxic effects of uranyl can be prevented by using chelating agent and complexation of the potentially multidentate ligands.