bcl-2 anti-apoptotic oncoprotein suppresses angiogenesis in non-small cell lung cancer: implications in resistance to photodynamic treatment?

摘要

Abstract: PDT cytotoxicity is likely to occur throughphotooxidative reactions. In that way mechanisms thatdefine poor oxygenation should be involved in definingresistance to photo-dynamic treatment (PDT). On theother hand bcl-2 anti- apoptotic protein has been shownto delay cell death and protect cells from toxicoxidative products. We examined 134 specimens fromT1,2-NO,1 staged patients treated with surgery alone.Specimens were immunohistochemically examined forvascular grade using the JC70 MoAb, and bcl-2oncoprotein expression. Bcl-2 expression correlatedwith low vascular grade. Only 3/27 of bcl2$PLU case hadhigh angiogenesis vs. 34/107 of cases without bcl-2expression. In the present study we provide evidencethat bcl-2 overexpression directly suppressesangiogenesis in non-small cell lung cancer, whichobviously results in decreased blood supply andoxygenation. This finding implies that reducedintratumoral angiogenesis and immortalizing oncoproteinoverexpression are linked to each other and may have arole in defining tumors resistant to PDT. !9