Self-assembly of PEI Modified Biodegradable Complex Micelles as Gene Transfer Vector for Proliferation of ECs

摘要

A complex micellar gene delivery system with a biodegradable core and a mixed shell was prepared using grafting low molecular weight PEI onto biodegradable PLGA backbone. The hydrodynamic size and zeta potential of blank and gene-loaded micelles indicated that they were feasible to cellular uptake and gene transfection. These complex micelles could change the ratio of mPEG/PEI easily to adjust the cytotoxicity and the transfection efficiencies.