Pegylated Human Growth Hormone: Biochemical Properties of a Series of Conjugates

机译：聚乙二醇化的人类生长激素：一系列缀合物的生化特性

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A series of mono- and multi-pegylated hGHconjugates was prepared using amine-selectivepolyethylene glycol (PEG) reagents. PEG polymersof varied length, geometry and activation chemistrywere chosen to evaluate PEG-hGH product yieldsand biochemical characteristics. Mono-pegylationwith PEG-ALD reagents resulted in the highestoverall yield and product homogeneity.

机译：一系列单PEG化和多PEG化的hGH 使用胺选择性制备偶联物聚乙二醇（PEG）试剂。 PEG聚合物具有不同的长度，几何形状和活化化学选择以评估PEG-hGH产品的产量和生化特征。单聚乙二醇化使用PEG-ALD试剂可获得最高的总产量和产品均质性。

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《Controlled Release Society 31st annual meeting transactions: abstracts》|2004年|1-2|共2页
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Rory Finn; Barrett Thiele; John Finnessy; Wei Liao; Troii Hall; Peter Nicastro; Susan Martin; Ned Siegel;
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4. Pegylated Human Growth Hormone: Biochemical Properties of a Series of Conjugates [C] . Controlled Release Society annual meeting . 2004

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5. Plasticity of pituitary hormone secretion, expression and cell numbers within the anterior pituitary glands of human growth hormone-releasing hormone transgenic mice: Focus on galanin, growth hormone, and prolactin. [D] . Moore, Joseph Patrick, Jr. 1997

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Pegylated Human Growth Hormone: Biochemical Properties of a Series of Conjugates

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