Characterization of normal and native oral cancerous tissues by infrared spectroscopy

摘要

Abstract: Fourier transform IR spectroscopy of normal and cancerous human oral tissues have been studied in the mid IR frequency region. From this study, we observed that the cancerous tissues are having higher absorption than that of normal one. Further it is observed that there is a 13 cm$+$MIN@1$/ red shift for cancerous samples with respect to normal tissues at their maximum absorption. In order to quantify the spectral differences between normal and cancerous tissues, two ratio parameters R$-1$/ $EQ I$-1650$//I$-1546$/ and R$-2$/ $EQ I$-1650$//I$-1384$/ are introduced. From the ratio parameter R$-1$/, it is found that the critical value 2.1 classify the malignant from normal with a 93 percent sensitivity and 80 percent specificity. Similarity a critical value 3 is given for the ratio parameter R$-2$/ yielding 80 percent sensitivity and 100 percent specificity. !12