Application of a Liquid Chromatography-Mass Spectrometric Technology to Simultaneous Determination of Multi-Mycotoxin in Grain

摘要

真菌毒素又称霉菌毒素,是由镰刀菌、曲霉菌和青霉菌等真菌产生的次级有毒代谢产物.在作物的种植、收获、储运过程中,真菌毒素极易污染粮食及其制品,引起人或动物的急性和慢性中毒.目前已确认化学结构的真菌毒素约有400多种,这些毒素被归类为比合成污染物、植物毒素、食品添加剂或农药残留更重要的食源性风险因子,严重威胁人类和动物的健康.全世界至少100个国家通过法规或标准严格规定粮食中主要真菌毒素的限量,并建立了多种用于筛查、确认和定量等不同目的的检测方法对真菌毒素进行监控.%Mycotoxins are toxic natural secondary metabolites produced by several species of fungi on agricultural commodities both in the field,and during storage,mixing,and delivery of grain,human food and animal feed.The major classes of mycotoxins from the human and animal health perspective are aflatoxins,ochratoxin A,trichothecenes,fumonisins,zearalenone,and ergot alkaloids.Mycotoxins are potent toxins which cause food-borne and feed-borne intoxication,and many are cytotoxic,carcinogenic,mutagenic,or immunosuppressive.