Icarus zinc finger family decomposers and their uses

摘要

The present disclosure generally relates to compounds that bind to and act as degraders of IKAROS family zinc finger (IKZF) proteins, such as IKZF2 (Helios) and/or IKZF4 (Eos). The present disclosure further relates to the use of such compounds for the manufacture of a medicament for treating diseases and/or conditions, including cancer, via binding and degrading IKZF proteins, such as IKZF2 and/or IKZF4.