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Avian influenza and fowl adenovirus type 4 bi-combined genetic engineering subunit vaccine and method for preparing the same
Avian influenza and fowl adenovirus type 4 bi-combined genetic engineering subunit vaccine and method for preparing the same
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机译:禽流感和禽腺病毒4型bi组合基因工程亚单位疫苗及其制备方法
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摘要
The disclosure relates to the technical field of veterinary biological products, and discloses an avian influenza and fowl adenovirus type 4 bi-combined genetic engineering subunit vaccine. An antigen in the vaccine is a fusion antigen; the fusion antigen has a) avian influenza virus HA protein; b) fowl adenovirus fiber2 protein; c) a specific linker peptide located between the avian influenza virus HA protein and the fowl adenovirus fiber2 protein; the amino acid sequence of the specific linker peptide is as shown in SEQ ID NO:2. This vaccine contains the fusion antigen which can induce poultries to produce a high-level specific antibody to protect poultries from avian influenza and fowl adenovirus infection. Meanwhile, the disclosure also discloses a method for preparing the vaccine.
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机译:本发明涉及兽医生物制品技术领域,公开了一种禽流感与禽腺病毒4型双结合基因工程亚单位疫苗。疫苗中的抗原是融合抗原;该融合抗原具有a)禽流感病毒HA蛋白;b) 鸡腺病毒fiber2蛋白;c) 位于禽流感病毒HA蛋白和禽腺病毒fiber2蛋白之间的特异性连接肽;特定连接肽的氨基酸序列如SEQ ID NO:2所示。该疫苗含有融合抗原,可诱导家禽产生高水平的特异性抗体,以保护家禽免受禽流感和禽腺病毒感染。同时,本发明还公开了一种疫苗的制备方法。
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