AVIAN INFLUENZA AND FOWL ADENOVIRUS SEROTYPE-4 COMBINED GENETIC ENGINEERING SUBUNIT VACCINE AND PREPARATION METHOD THEREFOR

摘要

The present invention relates to the technical field of veterinary biological products, and provides an avian influenza and fowl adenovirus serotype-4 combined genetic engineering subunit vaccine. The antigen in the vaccine is a fusion antigen. The fusion antigen contains: a) avian influenza virus HA protein; b) fowl adenovirus fiber2 protein; and c) a specific linker peptide between the avian influenza virus HA protein and the fowl adenovirus fiber2 protein. The amino acid sequence of the specific linker peptide is as shown in SEQ ID NO: 2 in the sequence list. The vaccine contains a fusion antigen, which can induce fowls to produce high-level specific antibodies to protect the fowls from infection with avian influenza and fowl adenovirus. Moreover, the present invention also provides a preparation method for the vaccine.