Non-invasive prenatal testing method and devices based on double Z-score

摘要

The present invention relates to a non-invasive prenatal test method and apparatus based on a two-step Z-score, and more particularly, by applying the Z-score, one of the statistical methods, twice to greatly amplify the Z-score, It relates to a method and apparatus for improving accuracy. Therefore, the present invention reduces the possibility of false positives and false negatives of chromosomal abnormality determination by maximally separating the number of reads of a specific chromosome from the number of reads in a normal sample group by using the amplified two-step Z-score by two-step data processing, and It can be used to increase the accuracy of non-invasive prenatal testing.