The present invention relates to a non-invasive prenatal test method and apparatus based on a two-step Z-score, and more particularly, by applying the Z-score, one of the statistical methods, twice to greatly amplify the Z-score, It relates to a method and apparatus for improving accuracy. Therefore, the present invention uses the two-step Z-score amplified by the two-step data processing, by maximally separating the number of reads of a specific chromosome from the number of reads in the normal sample group, thereby reducing the possibility of false-positive and false-negative of chromosomal abnormality determination. It can be used to increase the accuracy of non-invasive prenatal testing.
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