USE OF TG02 FOR TREATING GLIOMAS IN PEDIATRIC SUBJECTS

摘要

The present disclosure relates to uses of TG02, for treating a glioma in a pediatric human subject. In certain embodiments, the glioma can be a pediatric high-grade glioma (PHGG), e.g, a diffuse intrinsic pontine glioma (DIPG), and/or a H3.3 -mutated glioma (e.g, a H3K27M-mutated glioma). The present disclosure further provides pharmaceutical compositions and kits that include an ERK5 inhibitor.