CROSS-IMMUNIZING ANTIGEN VACCINE AND METHOD FOR PREPARATION THEREOF

摘要

The present invention provides a fusion polypeptide that induces a humoral immune response and a cellular immune response to a virus, containing antigens or fragments thereof of the following (a) and (b), and having an oligomerization activity:(a) an antigen of the virus or a fragment thereof containing a B cell epitope conserved among subtypes of the virus; and(b) an antigen of the virus or a fragment thereof containing a T cell epitope conserved among subtypes of the virus(wherein the antigen(s) or the fragment(s) thereof of (a) and/or (b) have an oligomerization activity, or the fusion polypeptide further contains (c) a polypeptide having an oligomerization activity in addition to the antigens or the fragments thereof (a) and (b)).