A method for improving center segregation and surface crack of continuous casting medium-thick slab of peritectic steel reduces the cooling intensity at the earlier stage of solidification and enhancing the cooling intensity at the final stage of solidification. For example, the cooling water amount of the wide face of the mould is 3400-3600 L/min, and the cooling water amount of the narrow face of the mould is 480-530 L/min. The cooling water amount of the wide face of the foot roller section is 239-298 L/min, and the cooling water amount of the narrow face of the foot roller section is 61-65 L/min. The total cooling water amount of the sector segment is 1517-2166 L/min.
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