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CELL-BASED ASSAY FOR DETERMINING THE IN VITRO TUMOR KILLING ACTIVITY OF CHIMERIC ANTIGEN EXPRESSING IMMUNE CELLS
CELL-BASED ASSAY FOR DETERMINING THE IN VITRO TUMOR KILLING ACTIVITY OF CHIMERIC ANTIGEN EXPRESSING IMMUNE CELLS
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机译:基于细胞的测定,用于测定表达免疫细胞的嵌合抗原的体外肿瘤杀灭活性
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摘要
The disclosure provides an in vitro method for determining potency (e.g., cytotoxicity) of an immune cell expressing a chimeric antigen receptor (CAR) molecule. In a test sample, CAR- expressing immune cells are incubated with target cells expressing an antigen which interacts with the CAR. In a control sample, the CAR-expressing immune cells are incubated with the target cells and an inhibitory molecule that prevents interaction between the CAR and the target cells. The amount of target cell death is determined in both the test sample and the control sample and is compared.
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