High binding activity WT1 T cell receptor and uses thereof

摘要

The present disclosure discloses a highly functional tumor-associated antigen p37 from Wilms tumor protein 1 (WT1) for use in treating a disease or disorder in which cells overexpress WT1 and/or produce a p37 antigen, such as in cancer. Provided are T cell receptors (TCRs) and related binding proteins having binding activity, T cells expressing such high affinity WT1 specific TCRs, nucleic acids encoding the same, and compositions.